Senescence in Chronic Kidney Disease
Trials applying stem cells for the treatment of diabetic kidney disease (DKD) will soon be under way. Autologous (from the patient) over allogeneic transplantation is the preferred option. However, success with cellular therapy in DKD patients may be limited by a frailty phenotype and “unhealthy” stem cells due to cellular senescence. The purpose of this study is to examine the effect of two drugs on mesenchymal stem cells, physical body function (or frailty), kidney function, and total clearance of senescent cells. Information from these investigations will help design preconditioning protocols for clinical trials applying stem cells for the treatment of ...
Evaluating Stem Cell Function in Patients with Chronic Kidney Disease (CKD)
New treatments of the future may use stem cells, cells that naturally occur in our blood or belly/abdominal fat, to help people with kidney disease. The purpose of this study is to understand the function of specific cell types and how well they may work to repair our kidneys. Two cell groups, mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), will be examined. Study participants will include individuals with varying degrees of kidney function and potential causes of kidney disease. This information will help plan for future studies using stem cells to treat kidney disease.
Pyridorin in Diabetic Nephropathy
The purpose of this study is to evaluate the safety and efficacy of oral Pyridorin 300 mg BID in reducing the rate of progression of nephropathy due to type 2 diabetes mellitus.
Determinants of Diabetic Nephropathy in American Indians
Scottsdale/Phoenix, AZ; Rochester, MN
The purpose of this study is to examine the evolution of diabetic kindey injury over an extended period in a group of subjects who previously completed a clinical trial which assessed the ability of losartan to protect the kidney from injury in early diabetic kidney disease. We will also explore the relationship between diabetic kidney disease and other diabetes complications, including neuropathy and retinopathy.