demyelinating disease

Displaying 10 studies

  • MRI Markers in Multiple Sclerosis Rochester, MN

    The purpose of this study is to develop quantitative approaches of analyzing multimodal MRI acquisitions with the goal to improve cortical lesion detection in all stages in MS, and to understand the interplay between cortical lesions, white matter lesions and functional connectivity network disruptions.

  • A Study to Better Understand if Diet and Metabolism are Connected with MS Relapses and Disease Progress in Patients with Pediatric-onset MS Rochester, MN

    The purpose of this research study is to better understand if diet and metabolism are connected with MS relapses and disease progress in patients with pediatric-onset MS.

  • A Study of the Effect of MD1003 in Progressive Multiple Sclerosis (SPI2) Scottsdale/Phoenix, AZ

    The purpose of this study is to demonstrate the superiority of MD1003 (300 mg/day) over placebo to clinically improve patients with progressive multiple sclerosis (MS).

  • A Study to Evaluate Sex Differences in Multiple Sclerosis Spectrum of Demyelinating Disorders Rochester, MN

    The purposes of this study are to explore the association between female sex, reproductive history and clinical phenotypic variability in multiple sclerosis (MS), to explore the association between female sex, reproductive history and radiologic phenotypic variability in MS, and to explore the association between female sex, genetic and environmental interactions in MS.

  • Maintenance Plasma Exchange for Neuromyelitis Optica Scottsdale/Phoenix, AZ; Rochester, MN

    Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system that is associated with autoantibodies to aquaporin-4. Treatment options for prevention of clinical relapses of NMO include immunosuppressive medications. Plasma exchange (PLEX) is commonly used as a rescue therapy for NMO relapses but ongoing, regular PLEX procedures (maintenance PLEX) is sometimes used to prevent relapses. This observational registry will record feasibility, tolerability, safety, and preliminary efficacy data regarding maintenance PLEX for NMO.

  • A Study for Long-Term Follow-up of Patients with Multiple Sclerosis who Participated in Previous Study of Alemtuzumab Scottsdale/Phoenix, AZ

    The purpose of this study is to evaluate the long-term safety, effectiveness, and patient reported quality of life outcomes of treatment with alemtuzumab for patients who have multiple sclerosis and participated in a previous study of alemtuzumab.

  • A Study to Evaluate Patient-Family Views on Pediatric MS Research Needs, Outcomes, and Methods Rochester, MN

    The primary purpose of this study is to determine patients' and families' priorities regarding clinical research studies and perceived barriers to pediatric onset multiple sclerosis (POMS) patients/family participation in research and interventional therapeutic studies.

  • Assessment of Tecfidera® in Radiologically Isolated Syndrome (RIS) Rochester, MN

    The purpose of this investigation is to systematically study the efficacy of Tecfidera in those individuals who possess incidental white matter anomalies within the brain following a MRI study that is performed for a reason other than for the evaluation of MS (multiple sclerosis).

  • A Study of Demyelinating Lesions as a Cause of Progressive Motor Deterioration Rochester, MN

    The purpose of this study is a comprehensive review of the clinical and radiologic history in these patients as well as review of neuropathology in deceased patients, where available.  The goal of this research is to investigate the hypothesis that this presentation represents a spatially limited form of CNS inflammatory demyelinating disease.

  • Long Term Clinical Outcomes of Devic’s Disease Rochester, MN; Jacksonville, FL

    Aims, purpose, or objectives:

    1. To describe the clinical features along with treatment outcomes of a cohort of patients with a diagnosis of NMOSD after the latest revised criteria in 2015 by International Panel for Neuromyelitis Optica Diagnosis (IPND)
    2. To described the long term outcomes of a cohort of patients with a diagnosis of NMOSD
    3. To identify demographic, clinical and radiologic factors associated with long terms outcomes of NMOSD
    4. To determine if patients who are diagnosed with the revised 2015 IPND criteria, in particular those who do not satisfy previous criteria, are ultimately diagnosed with ...


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