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MCF Cystic Kidney and Liver Disease Biobank
Jacksonville, FL
The purpose of this study is to
evaluate the potential of PAPP-A as a therapeutic target in ADPKD, we collaborated with Calico and performed the following studies under a sponsor research agreement (SRA) using an anti-PAPP-A monoclonal antibody (anti-PAPP-A) developed by Calico. These studies demonstrated an improvement in total kidney volume (TKV), reduction in cystic and tumor burden, and beneficial effects in survival, frailty index, and renal function.
Thus, our published studies and the preclinical studies performed under the Calico SRA confirm that the IGF/PAPP-A pathway is a therapeutic target in ADPKD, and that anti-PAPP-A treatment is beneficial ...
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Predicting Disease Progression in Pediatric Patients With Autosomal Dominant Polycystic Kidney Disease Using Urinary Crystal Burden as a Biomarker
Rochester, MN
The purpose of this study is to characterize urinary crystalluria, supersaturation, cytokines, and extracellular vehicles from activated renal tubular epithelial cells, interstitial monocytes, and pro-and anti-inflammatory macrophages in a cohort of male and female pediatric patients with autosomal dominant polycystic kidney disease (ADPKD). Also, to determine cross-sectional associations between cyst burden/kidney function and urinary crystalluria, supersaturation, cytokines, and extracellular vehicles (EVs).
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A Study Of RGLS8429 In Patients With Autosomal Dominant Polycystic Kidney Disease
Jacksonville, FL; Rochester, MN
The purpose of ths study is to assess the safety and tolerability of RGLS8429. Addiitionally, to assess the impact of RGLS8429 on ADPKD biomarkers
Other objectives are o assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV) and to characterize the pharmacokinetic (PK) properties of RGLS8429 -To assess the impact of RGLS8429 on renal function.
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A Study To Compare Somatostatin Analogues With Perioperative Antibiotics Versus Prolonged Antibiotics
Rochester, MN
The purpose of this study is to to determine the individual treatment effect of somatostatin and whether duration of antibiotic therapy coupled with octreotide provides improved outcomes after pancreaticoduodenectomy.