Clinical Trials

cystic disorders

Displaying 3 studies

Predicting Disease Progression in Pediatric Patients With Autosomal Dominant Polycystic Kidney Disease Using Urinary Crystal Burden as a Biomarker Rochester, MN

The purpose of this study is to characterize urinary crystalluria, supersaturation, cytokines, and extracellular vehicles from activated renal tubular epithelial cells, interstitial monocytes, and pro-and anti-inflammatory macrophages in a cohort of male and female pediatric patients with autosomal dominant polycystic kidney disease (ADPKD). Also, to determine cross-sectional associations between cyst burden/kidney function and urinary crystalluria, supersaturation, cytokines, and extracellular vehicles (EVs).
A Study Of RGLS8429 In Patients With Autosomal Dominant Polycystic Kidney Disease Jacksonville, FL; Rochester, MN

The purpose of ths study is to assess the safety and tolerability of RGLS8429. Addiitionally, to assess the impact of RGLS8429 on ADPKD biomarkers

Other objectives are o assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV) and to characterize the pharmacokinetic (PK) properties of RGLS8429 -To assess the impact of RGLS8429 on renal function.
A Study To Compare Somatostatin Analogues With Perioperative Antibiotics Versus Prolonged Antibiotics Rochester, MN

The purpose of this study is to to determine the individual treatment effect of somatostatin and whether duration of antibiotic therapy coupled with octreotide provides improved outcomes after pancreaticoduodenectomy.