alcoholic hepatitis

Displaying 6 studies

  • Safety and Efficacy of IMM 124-E for Patients with Severe Alcoholic Hepatitis Rochester, MN

    Hypothesis: Oral administration of hyperimmune bovine colostrum enriched with anti-LPS antibodies will reduce endotoxemia, and improve pathophysiological and clinical parameters related to severe alcoholic hepatitis (SAH).

    Aim: To perform a phase 2a "proof of concept" placebo-controlled, dose-ranging study of Imm 124-E (hyperimmune bovine colostrum enriched with IgG anti-LPS) in subjects with severe AH on steroids.

  • Study to Assess Alcoholic Hepatitis with Multiparametric Magnetic Resonance Elastography Rochester, MN

    All 20 patients requiring a liver biopsy for inclusion in our clinical trials will undergo a hepatogram examination within 72 hours of screening and prior to randomization. Inclusion and exclusion criteria for patients are identical to that proposed in the associated clinical trials. In addition to the strict exclusion criteria addressed in RFA AA-18-002 and RFA AA-18-005, we will exclude patients with claustrophobia.

     

  • Study of IDN-6556 in Patients With Severe AH and Contradictions to Steroid Therapy Rochester, MN

    The main purpose of the study is to test if taking a study drug called emricasan (also known as IDN-6556 and PF-03491390) will affect overall patient survival after one month of treatment.

  • A Study to Establish an Alcoholic Hepatitis Network Rochester, MN

    The purpose of this study is to create a clinical database and bio-repository by obtaining blood, urine, and stool samples (e.g., biological samples) and personal health information from patients to use in future research studies related to alcoholic hepatitis or other diseases.

  • Use of F-652 in Patients With Alcoholic Hepatitis Mankato, MN; Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN

    Alcoholic hepatitis is a syndrome of progressive inflammatory liver injury associated with long-term heavy intake of ethanol. The pathogenesis is not completely understood. Patients who are severely affected present with subacute onset of fever, hepatomegaly, leukocytosis, marked impairment of liver function (e.g., jaundice, coagulopathy), and manifestations of portal hypertension (e.g., ascites, hepatic encephalopathy, variceal hemorrhage). However, milder forms of alcoholic hepatitis often do not cause any symptoms. Alcoholic hepatitis usually persists and progresses to cirrhosis if heavy alcohol use continues. If alcohol use ceases, alcoholic hepatitis resolves slowly over weeks to months, sometimes without permanent sequelae but often with residual ...

  • A Study to Evaluate Whether or Not Extracellular Counts and Content Can Diagnose Alcoholic Hepatitis Rochester, MN

    The purpose of this study is to determine if extracellular (EV) counts and content can differentiate Alcoholic Hepatitis (AH) from alcoholic liver disease as well as end stage liver disease due to other causes.

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