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A Study Of Vocal Biomarkers For Detecting Lung Cancer

Overview

About this study

The Primary objective of this research is to identify differences in the vocal characteristics of individuals with confirmed lung cancer, cancer-free individuals with benign lung nodules, and Individuals with similar risk factors for lung cancer with no pulmonary nodules.  If statistically significant group‑level voice differences are found, we will develop a machine‑learning prediction model that classifies individuals as lung‑cancer‑positive or negative based on their vocal profile

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age >40 years.

  • Able to read and understand English.

  • Willing and able to sign the informed consent.

  • Have access to a cell phone which can access the voice recorder app.

 Exclusion Criteria:

  • Current upper respiratory tract infection.

  • History of significant speech or voice disorder affecting lung health.

  • Current use of voice-modifying treatments (e.g., laryngeal surgery, vocal fold injections).

  • Any participant with a prior history of cancer prior to recruitment, to ensure the study population is not confounded by previous malignancy.

  • Patients who have undergone any invasive head or thoracic procedures within the past 30 days prior to study participation.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/21/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Sebastian Fernandez-Bussy, M.D.

Contact us for the latest status

More information

Publications

Publications are currently not available

More about research at Mayo Clinic

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CLS-20603070

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