Clinical Trials

Inclusion Criteria:

• Age ≥18 years

• Admitted to an adult ICU at Mayo Clinic Rochester

• Currently on mechanical ventilation receiving continuous propofol infusion

• Has been on mechanical ventilation with propofol for at least 24 hours

• The clinical team expects the patient to remain intubated

• No active plans for transition to comfort care measures

• Legally authorized representative available for consenting (if patient lacks decision-making capacity)

Exclusion Criteria:

• Transfer from an outside hospital where propofol was already being administered at the time of ICU admission (rationale: unable to obtain baseline pre-propofol triglyceride level from stored pre-intubation specimens)

• Anticipated extubation within 24 hours of screening (rationale: insufficient time to observe P-HTG development and resolution patterns)

• Patient or LAR declines participation

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 04/06/2026. Questions regarding updates should be directed to the study team contact.