Hemang Yadav, M.B.B.S., studies the epidemiology, pathophysiology and management of patients admitted to intensive care units (ICUs) with respiratory failure, lung injury and acute respiratory distress syndrome (ARDS). Dr. Yadav aims to improve understanding of the immunology of ARDS through the analysis of biomarkers to improve current tools for predicting who develops ARDS, to identify potentially modifiable risk factors for ARDS in immunocompromised patients, and ultimately to develop novel ARDS prevention strategies. Dr. Yadav is also interested in the epidemiology of seasonal and pandemic influenza, as well as the utility of prognostic scoring systems in multiorgan failure and sepsis.
- Respiratory failure in patients after hematopoietic stem cell transplantation (HSCT). Dr. Yadav is focused on furthering the understanding of why patients who undergo HSCT develop respiratory failure after transplantation. His epidemiological work has highlighted the frequency and devastating impact of ARDS on patients who have undergone stem cell transplantation. Dr. Yadav is currently investigating how novel and potentially modifiable risk factors affect patients' chances of developing ARDS after stem cell transplantation.
- Biomarkers in ARDS. Dr. Yadav is studying the pathophysiology and immunology of postoperative ARDS by analyzing the temporal profile of key biomarkers in the perioperative period. His aim is to integrate biomarkers into clinical scoring systems to better identify those at risk of developing ARDS.
- Comparative effectiveness of therapies in seasonal influenza. Dr. Yadav is studying the epidemiology of hospitalized individuals with seasonal influenza and how the timing of key interventions such as antiviral medications, corticosteroids and antibiotics affect patient outcomes.
- Severity scoring systems in the ICU. Dr. Yadav is interested in furthering the utility of severity scoring systems in critical care settings. He has improved the Sequential Organ Failure Assessment (SOFA) to significantly outperform the existing SOFA and is working on developing further modifications to this scoring system.
Significance to patient care
Acute respiratory distress syndrome (ARDS) is a frequent complication after HSCT, dramatically influencing patient survival and quality of life. To date, effective treatments for established ARDS are few, and the impact of ARDS for individual patients can be devastating. Dr. Yadav's hope is that a better understanding of the risk factors, immunology and pathophysiology of ARDS can help identify those patients at increased risk of developing ARDS in the post-transplant period. His long-term research focus is to then develop targeted preventive strategies for high-risk individuals in order to prevent ARDS before it occurs.
- Recipient, Specialty Award for Research in Hematology, Society of Critical Care Medicine, 2015
- Recipient, Specialty Award for Research in Pulmonary Medicine, Society of Critical Care Medicine, 2015
- Recipient, Outstanding Achievement in Residency Award, Mayo Clinic, 2013
- Recipient, proxime accessit to the Gold Medal, University of London, 2007