A Study of LNK01002 in Patients With Primary (PMF) or Secondary Myelofibrosis (PV-MF, ET-MF) or Acute Myeloid Leukemia

Overview

About this study

The purpose of this study is to evaluate safety and tolerability of multi-kinase inhibitor LNK01002 in patients with primary myelofibrosis (MF), or MF due to polycythemia vera (PV-MF), or essential thrombocythemia (ET-MF), or with acute myeloid leukemia (AML).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age: 18 years old or older, male or female.
  • Patients must have histologically or cytologically confirmed tumors of the following types.
  • Dose Escalation Phase:
    • Patients with PMF, PV/ET-MF;
    • Intermediate or high-risk primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential thrombocythaemia myelofibrosis which failed standard treatment;
    • Symptomatic splenomegaly;
    • Not undergone splenectomy or splenic radiation therapy within 6 months prior to screening.
  • Dose expansion phase:
    • Patients with PMF, PV/ET-MF who relapsed or are intolerant to standard treatment, and relapsed/refractory AML.
  • Platelet count ≥ 100 × 10e^9/L within 14 days before study drug administration.
  • Absolute neutrophil count (ANC) ≥ 1.5 × 10e^9/L within 14 days before study drug administration.
  • Women of childbearing potential negative pregnancy test at screening. Female patients of childbearing potential, or male patients and their partners should agree to effective contraception from signing ICF until 6 months after the last dose of study drug.

Exclusion Criteria:

  • Allergic to any component of LNK01002.
  • Serum total bilirubin greater than 1.5 times the upper limit of the normal (ULN) reference range, except patients diagnosed as Gilbert's disease.
  • ALT or AST higher than 3 times the ULN reference range without hepatic involvement by leukemia, which are excluded if higher than 5 times the ULN.
  • Glomerular filtration rate or estimated creatinine clearance < 50 mL/min according to the Cockcroft-Gault formula.
  • Serum amylase or lipase levels higher than the ULN and considered clinically significant.
  • International normalized ratio (INR) or partial activated prothrombin time (aPTT) above 1.5 times the ULN reference range.
  • Known history of clinically significant liver disease, including viral or other hepatitis:
    • Patients with hepatitis B or hepatitis C may be enrolled if they have a negative polymerase chain reaction (PCR);
    • Known human immunodeficiency virus (HIV) infection.
  • Clinically significant cardiovascular diseases, including acute myocardial infarction, unstable angina, coronary artery bypass surgery within 6 months before enrollment, congestive heart failure with New York Heart Association (NYHA) classification of III or above, left ventricular ejection fraction (LVEF) < 50%, or uncontrolled hypertension, cardiac arrhythmia.
  • Patients with history or presence of clinically relevant non-malignant CNS disease requiring treatment.
  • Patients who have received systemic antineoplastic therapy or radiotherapy within 2 weeks prior to start of study treatment.
  • Patients who have received hematopoietic stem cell transplantation (HSCT) within 60 days prior to the start of study treatment, or are receiving immunosuppressive therapy after HSCT at screening, or have graft-versus-host disease (GVHD) requiring drug control.
  • Received anti-tumor Chinese herbal medicine treatment within 1 week before the start of study treatment.
  • Received CYP3A substrates, CYP2B6 substrates, CYP2C substrates, OATP1B3 substrates, UGT1A1 inhibitors, or UGT1A3 inhibitors less than one week or 5 half-lives (whichever is longer) prior to the start of study treatment.
  • Uncontrolled, active infections requiring intravenous antibiotic treatment.

Eligibility last updated 10/14/21. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Talha Badar, M.B.B.S., M.D.

Closed for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

Rochester, Minn.

Mayo Clinic principal investigator

Naseema Gangat, M.B.B.S.

Closed for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available
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CLS-20534337

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