A Study to Evaluate the Correlation Between Aging and Bleeding in von Willebrand disease


About this study

The purpose of this study is to determine if people with type 1 VWD experience age related increases in VWF levels and what effect this has on bleeding in this population. In order to discover this, the study will examine medical history, blood and genetic tests for VWD and bleeding and collect information about bleeds from the subjects.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • New or historical diagnosis of type 1 VWD (defined as clinical symptoms consistent with VWD and VWF:Ag level or VWF:RCo activity < 0.50 IU/mL).
  • Age ≥ 18 years of age.

Exclusion Criteria:

  • < 18 years of age.
  • Concomitant hereditary bleeding disorder.
  • Pregnancy.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Rajiv Pruthi, M.B.B.S.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Tiffany Plowman

(507) 284-5095


More information


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