Evaluation of the Value of Exosomal DEL-1 and miRNA Levels as Biomarkers for Breast Cancer


About this study

The purpose of this study is to measure DEL-1 levels and develop and validate methods for measurement of the exosomal T-RNAs( miR 1274b and mirR 720) as well as four miRs ( miR 21, let-7a, miR 125b and miR 100) in pre and post tumor resection plasma samples from women with newly diagnosed localized breast cancer. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Women with a history of breast cancer enrolled in the Mayo Clinic in Florida breast cancer bio-bank project with pre- breast cancer surgery plasma available for further analysis.

  • Willing to give a post-surgical sample 1-12 months post-surgery

Exclusion Criteria: 

  • No pre-breast surgery plasma available.
  • Not willing to donate post-surgical specimen.
  • Not having a diagnosis of invasive breast cancer.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Gerardo Colon-Otero, M.D.

Closed for enrollment

Contact information:

Amanda Arnold


More information


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