Jacksonville, Florida


gcolonotero@mayo.edu Clinical Profile


The research of Gerardo Colon-Otero, M.D., is focused on the treatment of breast cancer and gynecologic malignancies (ovarian cancer, uterine cancer and cervical cancer) and on efforts to eliminate cancer care outcome disparities.

Dr. Colon-Otero collaborates with other scientists at Mayo Clinic to identify new treatments for gynecologic cancer and breast cancer aimed at overcoming the problem of tumor resistance. His research aims at identifying some of the genetic differences that may contribute to worse outcomes in different segments of the population.

In collaboration with community entities, his team develops community-based interventions aimed at ensuring underserved populations have adequate access to cancer screening and cancer research programs. Dr. Colon-Otero is also actively involved in the training of medical students, residents and fellows.

Focus areas

  • Breast cancer
  • Gynecologic cancer, including ovarian cancer, uterine cancer and cervical cancer
  • Cancer care disparities

Significance to patient care

All patients with breast cancer and gynecologic cancer that has spread eventually die of their cancer, mainly because their cancer becomes resistant to treatment. There is a need to identify the reasons for the tumor resistance so that new effective treatments can be developed.

Dr. Colon-Otero's team research has identified new drug combinations that are effective against ovarian cancer and are studying the mechanism by which these drug combinations may work.

African-American and Hispanic populations have worse outcomes for multiple cancers in part due to genetic reasons and access issues. Dr. Colon-Otero's team is working in collaboration with the community to find ways to ameliorate these disparities in outcome.

Professional highlights

  • Co-investigator, Robert Wood Johnson Foundation Health Policy training grant, 2016-present.
  • Principal investigator, Novartis grant, 2014-present.
  • Decentralized Clinical Trial Award, Increase Trial Access via Decentralization and Develop New Decentralized Capabilities categories, Mayo Clinic, 2023.
  • President, Florida Society of Clinical Oncology, 2012-2013.
  • Principal investigator, Palliative Care to Florida Society of Clinical Oncology from American Society of Clinical Oncology grant, 2011-2012.
  • Principal investigator, American Cancer Society grant, 2008.


Primary Appointment

  1. Consultant, Division of Hematology/Oncology, Department of Internal Medicine

Academic Rank

  1. Professor of Medicine


  1. Fellow - Medical Oncology and Hematology University of Virginia Medical Center
  2. Fellow - Hematology Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
  3. Resident Hematology, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  4. Internship/Residency - Internal Medicine Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
  5. Resident Internal Medicine, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  6. MD University of Puerto Rico School of Medicine
  7. BSc - Mathematics University of Puerto Rico, San Juan

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