SUMMARY
The research of Kianoush B. Kashani, M.D., M.S., focuses on:
- Acid-base balance and electrolytes.
- Acute kidney injury.
- Artificial intelligence (AI).
- Digital health.
- Education.
- Extracorporeal blood purification strategies.
- Extracorporeal membrane oxygenation.
- Fluid management.
- Kidney injury biomarkers.
- Kidney replacement therapies.
- Point-of-care ultrasonography.
- Simulation medicine.
Dr. Kashani has played a key role in the discovery and validation of two new biomarkers for acute kidney injury (TIMP-2 and IGFBP7), the development of the Sarcopenia Index, and the investigation of ultrasound elastography. He has also developed, validated and implemented several AI-driven support tools for managing the continuum of acute kidney injury and sepsis in the intensive care unit.
Dr. Kashani delivers international lectures on acute kidney injury, critical care education and fluid management in the intensive care unit. He has written numerous peer-reviewed publications and contributed chapters to several medical textbooks.
Focus areas
- AI. Dr. Kashani designs and validates computer-based tools to enhance the early detection and management of acute kidney injury. His work spans both static and real-time dynamic models as well as clinical decision support systems that assist in real-time care. He also creates automated tools to manage intradialytic hypotension, estimate baseline serum creatinine, and identify new nephrotoxic medications and their interactions. His research extends to predictive models for hemodynamic instability in patients with sepsis and heart failure. His studies also aim to develop digital twins to support personalized acute kidney injury management.
- Acute kidney injury prediction. Dr. Kashani leads efforts to improve early detection of acute kidney injury through the construction of biomarkers and predictive models. This work includes creating clinical and electronic tools aimed at preventing the progression of acute kidney injury.
- Acute kidney injury management. Dr. Kashani advances the management of acute kidney injury by implementing automated, AI-augmented decision support systems. His research focuses on enhancing fluid and vasopressor therapy in patients with high risk of progression and developing tools to assist clinicians in managing nephrotoxic exposures.
- Fluid and electrolyte management. Dr. Kashani investigates how to optimize fluid and electrolyte balances in patients who are critically ill. His work includes assessing diuretic resistance, creating interventions for volume overload in patients who are diuretic resistant, and evaluating how different types and rates of fluid administration affect patient outcomes. Dr. Kashani also explores the effects of electrolyte imbalances on recovery.
- Kidney monitoring. Dr. Kashani concentrates on innovations for noninvasive measurement and monitoring of kidney function, skeletal muscle mass, kidney hypoxia and kidney intracapsular pressure in real time.
- Education. Dr. Kashani aims to advance medical education by implementing quality improvement curricula and projects focused on intensive care unit outcomes — including acute kidney injury — and decreasing burnout among healthcare professionals.
Significance to patient care
Dr. Kashani's research is focused on helping healthcare teams recognize and treat kidney conditions — especially acute kidney injury — as early and effectively as possible. He develops and uses advanced tools such as AI to support real-time decisions in the intensive care unit, ensuring that patients receive the right care at the right time.
By helping healthcare teams identify kidney issues early, carefully manage fluids and avoid medicines that may harm the kidneys, Dr. Kashani's work helps improve the quality and safety of patient care. These efforts can reduce the need for dialysis, shorten hospital stays, and even lower the risk of serious complications or death.