A Study to Evaluate Specific Blockage of Angiotensine 2 and Podocyturia in Glomerular Nephropathies with Hypertension and Proteinuria

Overview

About this study

The purpose of this study is to quantify podocyturia during glomerular nephropathies by dosing podocyte microparticles ii) to study the relationship between podocyturia and other biologic markers such as proteinuria iii) to evaluate the effect of angiotensine 2 blockage on podocyturia.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria:

  • Hypertension (TAs > 130, TAd > 80mmHg or under antihypertensive treatment).
  • Glomerular nephropathy, proteinuria > 1 g/day, serum creatinin < 200 µmol/L.
  • Informed consent given.
  • No contraindication for ARB and hydrochlorothiazide.
  • Efficient contraception for women.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Gerardo Colon-Otero, M.D.

Open for enrollment

Contact information:

Gerardo Colon-Otero M.D.

(904)953-8510

gcolonotero@mayo.edu

Rochester, Minn.

Mayo Clinic principal investigator

Gerardo Colon-Otero, M.D.

Contact us for the latest status

Contact information:

Gerardo Colon-Otero M.D.

(904)953-8510

gcolonotero@mayo.edu

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Gerardo Colon-Otero, M.D.

Contact us for the latest status

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20467299

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