Hilal Maradit Kremers, M.D.

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SUMMARY

Hilal Maradit Kremers, M.D., studies the epidemiology and outcomes of musculoskeletal diseases and procedures. She uses clinical information collected during routine medical care such as that in electronic health records and joint replacement registries. She is implementing natural language processing techniques to extract medical concepts from the unstructured text of medical records and developing computer vision technologies for automated interpretation of musculoskeletal images for diagnostic and prognostic purposes. She serves as the principal investigator on several NIH-funded projects and as the collaborating epidemiologist on several others.

Dr. Maradit Kremers is the methodology core director of the NIAMS-funded P30 Core Center for Clinical Research in Total Joint Arthroplasty (CORE-TJA) at Mayo Clinic. CORE-TJA provides access to state-of-the-art methodological expertise, education and big data resources to accelerate methodologically rigorous clinical research that will directly improve the care and outcomes of patients who undergo hip and knee replacement.

Focus areas

• Safety of hip and knee replacement implants. There are concerns about the long-term safety of hip and knee implants, in part due to systemic distribution of metal debris from the implants. Dr. Maradit Kremers is working to understand the potential risk of cognitive decline and heart failure in patients with hip and knee replacements.
• Artificial intelligence research in orthopedics. Dr. Maradit Kremers uses natural language processing and machine learning technologies for automated data abstraction from unstructured electronic health records and for computer-aided classification of hip and knee replacement radiographs.
• Determinants of clinical outcomes and costs in total joint arthroplasty. Using the resources of the Mayo Clinic Total Joint Registry, Dr. Maradit Kremers examines how clinical heterogeneity, and implant and patient characteristics are associated with better or worse outcomes and costs in recipients of total knee and hip replacements.

Significance to patient care

Dr. Maradit Kremers' research into the long-term safety of total joint replacement implants and determinants of clinical outcomes will help enhance delivery of effective musculoskeletal care and improve outcomes for patients. Her research using artificial intelligence techniques will enhance use of electronic health records in orthopedics research and transform orthopedic imaging practice.