SUMMARY
The clinical and research interests of Bradley F. Boeve, M.D., include healthy aging, neurogenetics, neurological sleep disorders, and neurodegenerative diseases that cause cognitive impairment, dementia, or parkinsonism or related conditions.
Specific areas of interest include:
- Mild cognitive impairment.
- Alzheimer's disease.
- Pick's disease.
- Frontotemporal dementia.
- Primary progressive aphasia.
- Lewy body dementia, also known as dementia with Lewy bodies.
- Corticobasal degeneration.
- Progressive supranuclear palsy.
- Posterior cortical atrophy.
- Rapid eye movement (REM) sleep behavior disorder.
- Narcolepsy.
- Restless legs syndrome.
- Periodic limb movement disorder.
Focus areas
- Frontotemporal lobar degeneration. Frontotemporal lobar degeneration is the umbrella term encompassing frontotemporal dementia, primary progressive aphasia, corticobasal degeneration, progressive supranuclear palsy and related conditions. Dr. Boeve studies the clinical, neuropsychological, genetic, biofluid, neuroimaging and neuropathologic characteristics of frontotemporal lobar degeneration.
- Lewy body disease. Dr. Boeve studies the clinical, neuropsychological, genetic, biofluid, neuroimaging and neuropathologic characteristics of Lewy body disease. These characteristics can be present clinically as mild cognitive impairment, Lewy body dementia, also known as dementia with Lewy bodies, and related conditions.
- REM sleep behavior disorder. Dr. Boeve studies the clinical, neuropsychological, genetic, biofluid, neuroimaging, polysomnographic and neuropathologic characteristics of REM sleep behavior disorder. Many people with REM sleep behavior disorder develop Lewy body dementia or Parkinson's disease later in life. Therefore, this relatively common sleep disorder is worthy of further study.
- Alzheimer's disease. Dr. Boeve studies the clinical, neuropsychological, genetic, biofluid, neuroimaging and neuropathologic characteristics of typical and atypical Alzheimer's disease.
Significance to patient care
Dr. Boeve's research leads to better care for people with brain diseases that get worse over time. His work includes building better tools to predict who may develop brain diseases, finding brain diseases as early as possible, treating symptoms more effectively and participating in clinical trials.
He is particularly interested in how treatments can slow these diseases, delay when they start, or prevent dementia and Parkinson-like movement issues.
Professional highlights
- Mayo Clinic:
- Chester and Debbie Cadieux Director, Alzheimer's Disease Research Center, 2025-present.
- The Little Family Foundation Professor of Lewy Body Dementia, 2018-present.
- Co-principal investigator, ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Consortium, 2020-present.
- Co-principal investigator, North American Prodromal Synucleinopathy Consortium, 2018-present.
- Site principal investigator, Research Centers of Excellence Program, Lewy Body Dementia Association, 2017-present.
- Co-principal investigator, Longitudinal Imaging Biomarkers of Disease Progression in Dementia with Lewy Bodies, 2016-present.