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Glaucoma is the leading cause of preventable blindness in the developed world, with over 2.5 million people affected in the United States alone, and 60 million people affected worldwide. Intraocular pressure (IOP) is the primary risk factor in glaucoma, and lowering of IOP is the only effective treatment for glaucoma at this time. However, with current technology, IOP can only be practically measured while patients are in clinic and routine practice involves measurements only a few times a year. Mounting evidence indicates that this approach is inadequate for optimal management of glaucoma since IOP varies with random fluctuations as well as a circadian rhythm with peak IOP occurring during the sleeping hours. Furthermore, the physiologic reasons for these IOP variations are poorly understood, resulting in an incomplete understanding of glaucoma pathophysiology and the mechanisms of glaucoma therapies.
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