Prophylactic Benzodiazepine versus Reinstitution of Maintenance Antiseizure Drugs following Ictal SPECT


About this study

The primary aim of this study is to compare the pre- and post-single photon emission computed tomography (SPECT) seizure frequency following an IV benzodiazepine protocol versus reinstitution of maintenance antiseizure drugs (ASDS).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age >18
  • Admitted to Mayo Clinic Florida EMU
  • Patients with medically refractory focal epilepsy

Exclusion Criteria: 

  • Patients with generalized epilepsy
  • Patients with epileptic seizures coexisting with psychogenic non-epileptic seizures
  • Patients with previous history of SISCOM related complication
  • Patients who are allergic to the radioisotope (Technetium Tc99m Exametazime)
  • Pregnant women
  • Patients who refuse to participate in the study

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

William Tatum, D.O.

Closed for enrollment

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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