Jacksonville, Florida


Tatum.William@mayo.edu Clinical Profile


William Tatum, D.O., is a neurologist subspecializing in the field of epilepsy and working with patients with recurrent seizures. My research interests reside in the medical and surgical treatment of patients with drug-resistant epilepsy focusing on epilepsy surgery and neuromodulation. Of interest are seizure semiology and behavioral aspects, including symptoms of seizures and the application of video-EEG monitoring. In addition, my primary area of research and interest is focused on all forms of EEG recording and clinical neurophysiology.

Focus areas

  • EEG and clinical neurophysiology. Dr. Tatum's research areas have included aspects of temporal lobe epilepsies, ambulatory EEG and video-EEG monitoring — resulting in published guidelines — and electrocorticography evaluating brain signals that subserve treatment pathways.
  • Epilepsy surgery. Areas of investigation have included the use of invasive electrodes for diagnosis and functional brain mapping, laser interstitial thermal therapy, and all forms of neuromodulation.
  • Seizure semiology. Clinical research has focused on behavioral signs and symptoms in patients with seizures with a special interest in the diagnostic use of smartphones to guide management.

Significance to patient care

Dr. Tatum's clinical research involving intraoperative electrocorticography has resulted in a patented recording device and an additional disclosure that has published results. For neurological and neurosurgical treatment of patients with brain tumor-related epilepsy, these results show that using a noncommercially available specialized recording technique yields improved outcomes. Additionally, Dr. Tatum and his colleagues have demonstrated that experts using smartphone video analysis can differentiate between epileptic and nonepileptic seizures with a high level of accuracy in the outpatient clinical setting.

Professional highlights

  • Editor-in-chief, Epilepsy & Behavior Reports, 2015-2023.
  • American Academy of Neurology.
    • Chairman, Section of Clinical Neurophysiology, 2018-2022.
    • A.B. Baker Teacher Recognition Honor Role, 2014.
  • Principal investigator, The Effect of an Adjunctive Anti-Seizure Medication Using a Glutaminergic Modulator in Patients with Focal Epilepsy and Glioma, Eisai Inc., 2019-2020.
  • Medical Book Award, British Medical Association, 2019.
  • Outstanding faculty member, Mayo Clinic School of Continuous Professional Development, 2018.
  • President, American Clinical Neurophysiology Society, 2015-2016.
  • President, American Board of Clinical Neurophysiology, 2013-2015.


Primary Appointment

  1. Consultant, Department of Neurology

Joint Appointment

  1. Consultant, Department of Neurosurgery

Academic Rank

  1. Professor of Neurology


  1. Fellow Graduate Hospital, University of Pennsylvania
  2. Resident Foster McGaw Hospital/Loyola University Medical Center, Loyola University Chicago
  3. Resident Edward Hines, Jr Veterans Administration Hospital
  4. Internship - Rotating Internship Suncoast Hospital
  5. Doctor of Osteopathic Medicine - Osteopathy College of Osteopathic Medicine and Health Sciences/College of Osteopathic Medicine and Surgery, Des Moines University
  6. BA - Pre-medicine Ohio Northern University

Clinical Studies

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