A Study to Evaluate Possible Changes in the Leg Muscles in Patients Taking Prednisone


About this study

The purpose of this study is to investigate the changes in the force production by the leg muscles that may occur while taking prednisone.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • 20 years in age or older
  • Any form of systemic idiopathic vasculitis
  • Initiated prednisone treatment (≥40mg per day) within the past 14 days
  • No signs of clinically defined muscle weakness

Exclusion Criteria: 

  • Other major co-morbidity
  • Presently on anticoagulant therapy
  • Unable to complete the experimental procedures due to physical or mental limitations
  • History of central or peripheral nerve disorder
  • History of myopathy or musculoskeletal pathology
  • History of spine or peripheral nerve surgery
  • Bleeding disorders
  • Currently pregnant – pregnancy will be determined through a pregnancy test


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Kenton Kaufman, Ph.D.

Closed for enrollment

More information


Publications are currently not available

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