A Study to Measure the Connection of Cause and Effect in Muscle Contraction, and Changes Caused by Aging


About this study

The purpose of this study is to learn about and measure changes in muscle contraction that happen as healthy people age. The connection between electrical activity causing muscles to contract and the pressure created as muscles contract will be studied.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Twelve healthy, young individuals between the ages of 21 and 40 years
  • Twelve healthy, older adults between the ages of 60 to 80 years of age
  • Good neuromuscular health
  • Women of childbearing potential are included in the subject population

Exclusion Criteria

  • History of central or peripheral nervous system disorders, myopathy, or musculoskeletal pathology
  • Current use of medications that affect muscle strength (e.g. corticosteroids, statins)
  • History of surgery of the lower extremities
  • Bleeding disorders
  • Current use of blood-thinning medications
  • Women who are pregnant will also be excluded from this study.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Kenton Kaufman, Ph.D.

Closed for enrollment

More information


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