Comparison of Bacteriostatic Saline to Buffered Lidocaine for Ultrasound Guided Hip Joint Injection Local Anesthesia


About this study

Local anesthesia is commonly used to reduce pain during joint injections, particularly for deep joints like the hip. Lidocaine is the most commonly used local anesthetic in most medical practices. It is well known that lidocaine infiltration itself is painful. Many strategies have been studied to minimize pain associated with lidocaine administration, including buffering, warming, and slowing infiltration rate. Bacteriostatic saline (BS) is an alternative local anesthetic that has been shown to be less painful when injected into subcutaneous tissues compared with lidocaine. However, BS use has not been widely implemented for local anesthesia, and it has not been studied in the context of joint injections. The purpose of this study is to compare infiltration pain and anesthetic efficacy between lidocaine and BS for ultrasound (US) guided intraarticular hip injections.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • age 18-75 years
  • referred for US-guided intraarticular hip injections in the Mayo Clinic Sports Medicine Center, PM&R Clinic, or Musculoskeletal Clinic

Exclusion Criteria:

  • chronic opioid use
  • opioid use on day of procedure
  • history of fibromyalgia or other diffuse chronic pain syndrome
  • pain behavior during the clinical encounter as judged by the injectionist
  • anesthetic administration time outside the designated 10-20 second time frame

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Jacob Sellon, M.D.

Closed for enrollment

More information


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Study Results Summary

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