Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications

Overview

About this study

This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced Red Blood Cells reduces pulmonary complications when compared to standard-of-care Leukocyte-Reduced Red Blood Cells in a cardiac surgical population.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria:

  • Age equal to or greater than 18 years of age.
  • Scheduled to have cardiac bypass surgery at Mayo Clinic in Rochester, Minnesota or Duke University Medical Center in Durham, North Carolina
  • At risk for needing at least 4 units of blood during/after surgery

Exclusion Criteria:

  • Emergency surgery
  • Immunoglobulin A (IgA) deficiency
  • History of severe recurrent transfusion reactions
  • Refusal to receive allogeneic blood products
  • Refusal to provide informed consent
  • Prevalent lung injury prior to randomization
  • Prevalent congestive heart failure prior to randomization
  • Expected hospital stay < 48 hours
  • Not anticipated to survive > 48 hours
  • Previously enrolled in this trial
  • No plan for placement of a pulmonary artery catheter
  • Use of home oxygen therapy
  • Complex RBC antibody profiles
  • Need for the use of irradiated RBCs

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Daryl Kor, M.D.

Closed for enrollment

Contact information:

Laurie Meade R.N.

(507)255-1829

Meade.Laurie@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20118031

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