The Patient-Centered Network of Learning Health Systems (LHSNet) is a clinical data research network funded by the Patient-Centered Outcomes Research Institute. Established in 2015, LHSNet aims to build the infrastructure to:

  • Facilitate patient-centered outcomes research
  • Support large pragmatic clinical trials and observational and interventional comparative effectiveness research studies embedded within health care systems
  • Enable dissemination, implementation and evaluation of clinical and community efforts to improve population health

LHSNet touches 13 states and brings together 10 diverse institutions, including academic medical centers, health care systems, a public health department and private health plans. Approximately 10 million people are served by these partners, including patients in underserved and rural areas.

The Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery coordinates Mayo Clinic's involvement in LHSNet.


Veronique L. Roger, M.D.

Sundeep Khosla, M.D.

Amy S. Eisenberg