The Patient-Centered Network of Learning Health Systems (LHSNet) was a clinical data research network funded by the Patient-Centered Outcomes Research Institute (PCORI). Funded between 2015 and 2019, LHSNet built infrastructure to:
- Facilitate patient-centered outcomes research
- Support large pragmatic clinical trials and observational and interventional comparative effectiveness research studies embedded within health care systems
- Enable dissemination, implementation and evaluation of clinical and community efforts to improve population health
LHSNet touched 13 states and brought together diverse institutions, including academic medical centers, health care systems, a public health department and private health plans. Its clinical research was focused on patients living with heart failure, osteogenesis imperfecta and obesity.
As a partner in the National Patient-Centered Clinical Research Network (PCORnet), LHSNet participated in seven research studies, building and populating a common data model that incorporated more than 15 million patients.
Read selected publications generated from Mayo Clinic's collaboration with LHSNet:
- Finney Rutten LJ, Alexander A, Embi PJ, Flores G, Friedman C, Haller IV, Haug P, Jensen D, Khosla S, Runger G, Shah ND, Winden T, Roger VL. Patient-Centered Network of Learning Health Systems: Developing a resource for clinical translational research. Journal of Clinical and Translational Science. 2017; doi:10.1017/cts.2016.11.
- Marquis-Gravel G, Roe MT, Robertson HR, Harrington RA, Pencina MJ, Berdan LG, Hammill BG, Faulkner M, Muñoz D, Fonarow GC, Nallamothu BK, Fintel DJ, Ford DE, Zhou L, Daugherty SE, Nauman E, Kraschnewski J, Ahmad FS, Benziger CP, Haynes K, Merritt JG, Metkus T, Kripalani S, Gupta K, Shah RC, McClay JC, Re RN, Geary C, Lampert BC, Bradley SM, Jain SK, Seifein H, Whittle J, Roger VL, Effron MB, Alvarado G, Goldberg YH, VanWormer JL, Girotra S, Farrehi P, McTigue KM, Rothman R, Hernandez AF, Jones WS. Rationale and Design of the Aspirin Dosing — A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness (ADAPTABLE) Trial. JAMA Cardiology. 2020; doi:10.1001/jamacardio.2020.0116.
During the five years of funding, LHSNet participating organizations and investigators built relationships and systems to enable continued connectivity in the future. Read more about LHSNet, its findings and continued legacy on the PCORI website.
The Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery coordinated Mayo Clinic's involvement in LHSNet.