Frontotemporal Degeneration (FTD) and Amyotrophic Lateral Sclerosis (ALS)

Tania Gendron, Ph.D., and Wilfried O. Rossoll, Ph.D., lead the research on frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (ALS) in the Discovery and Translation Labs at Mayo Clinic. With the goal of improving the prognosis and treatment of people with early-onset dementias and related disorders, the research seeks to identify novel causal genes and genetic risk factors, elucidate mechanisms of disease, and discover biomarkers and therapeutic targets.

Laboratories

• Comparative Pathogenesis of Alzheimer's Disease and Related Disorders: Casey N. Cook
• Dementia and Immunity: John D. Fryer
• Drug Discovery, Design and Optimization for Novel Therapeutics: Thomas Caulfield
• Genomics of ALS and Integrative Analytics: Marka Van Blitterswijk
• Memory Disorders: Neill R. Graff-Radford
• Neurobiology of Neurodegenerative Diseases: Wilfried Rossoll
• Neurodegenerative Diseases: Leonard Petrucelli
• Neuropathology and Microscopy: Dennis W. Dickson
• Pathomechanisms of Neurodegeneration in the Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Yongjie Zhang
• RNA Metabolism in Neurodegenerative Disease: Mercedes Prudencio
• Translational and Integrative Omics for Neurodegeneration: Veronique Belzil
• Translational Cell Biology of Parkinson's Disease: Wolfdieter Springer
• Translational Neurobiology of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Tania Gendron
• Translational Neuromuscular Disease Research: Nathan P. Staff

Faculty

• Thomas Caulfield, Ph.D.
• Casey N. Cook, Ph.D.
• Dennis W. Dickson, M.D.
• Tania Gendron, Ph.D.
• Neill R. Graff-Radford, M.D.
• Bjorn E. Oskarsson, M.D.
• Leonard Petrucelli, Ph.D.
• Mercedes Prudencio, Ph.D.
• Rosa Rademakers, Ph.D.
• Wilfried O. Rossoll, Ph.D.
• Beth K. Rush, Ph.D.
• Jaimin S. Shah, M.D.
• Wolfdieter Springer, Ph.D. 
• Nathan P. Staff, M.D., Ph.D.
• Marka M. Van Blitterswijk, M.D., Ph.D.
• Yongjie Zhang, Ph.D.