Brain tumor, breast cancer, colon cancer, congenital heart disease, heart arrhythmia. See more conditions.
The research of Yongjie Zhang, Ph.D., is focused on investigating disease mechanisms associated with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two fatal diseases that are pathologically and genetically related. Dr. Zhang has significant expertise in functional and molecular biology, as well as animal modeling.
Using an array of complementary tools, Dr. Zhang's laboratory is specifically interested in investigating the pathogenic pathways by which aggregation-prone proteins (such as TDP-43, C9orf72 dipeptide repeat protein) cause cellular functional defects and neurodegeneration, resulting in novel therapeutic strategies to mitigate toxicities associated with these abnormal protein deposits.
The ultimate goal of Dr. Zhang's research is to identify novel therapeutic targets and design target-specific therapies to successfully treat FTD and ALS.
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