The mission of the Center for Cell Signaling in Gastroenterology (C-SiG) at Mayo Clinic is to improve the health of people with digestive diseases. We do this by supporting research that enhances the understanding of the signaling pathways that control the function of gastrointestinal cells, both in health and disease.
Our center serves as a hub that provides access to state-of-the-art research resources and expertise through three biomedical research cores to multidisciplinary groups of basic scientists and clinical researchers.
To foster meaningful collaboration and coordinate research efforts, our center is organized by a matrix that includes three interconnected research themes that intersect with three disease focus groups. This matrix structure allows us to integrate research efforts from scientists and clinicians in a variety of fields, including biochemistry and molecular biology, physiology, biomedical engineering, molecular medicine, immunology, pathology, pharmacology, oncology, and gastroenterology and hepatology. This integration of multidisciplinary scientists and clinicians enables faster translation from the lab to clinical trials, ultimately improving digestive disease treatment.
The Center for Cell Signaling in Gastroenterology was established in 2009 as one of 17 Silvio O. Conte Digestive Disease Research Core Centers supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Learn more about these core centers.
Learn more about our leadership and governance.
Gastrointestinal diseases and related complications have a significant negative effect on public health and incur considerable health care costs. Advances in digestive diseases care requires an infrastructure that supports meaningful interactions among multidisciplinary scientists who study cellular mechanisms, pathways and therapeutic targets to enhance rapid translation of basic discoveries into clinical trials.
Our center works to provide this infrastructure. We support research that is critically important to advance the understanding of the processes that lead to digestive diseases. New knowledge can lead to practical applications to better diagnose, prevent, monitor and treat digestive diseases.
Goals of the Center for Cell Signaling in Gastroenterology are to support digestive disease research by:
- Fostering collaborative, multidisciplinary research. We bring together a diverse group of clinical and basic science investigators in a team-based approach to advance knowledge and technical capabilities.
- Providing access to cutting-edge, high-quality and cost-effective technologies, resources and skilled technical expertise through our three linked cores.
- Enhancing the collaborative environment and facilitating technology transfer via our robust and diverse Scientific Enrichment Program. This program offers seminars, workshops, symposia and web-based curricula.
- Identifying and nurturing fellows and junior faculty members engaged in digestive diseases research via the rigorously peer-reviewed Pilot and Feasibility Program.
- Promoting synergistic interactions with institutional partners and other Digestive Disease Research Core Centers (DDRCC), especially the Midwest DDRCC Alliance.
Shared resources foster productivity, synergy, and new research ideas and techniques in an efficient and cost-effective manner. Our center offers cutting-edge, specialized equipment, technologies, reagents, expertise and other services to assist faculty members and their research teams through three cores.