Biostatistics and Bioinformatics Core

The Biostatistics and Bioinformatics Core provides statistical, bioinformatics and computational biology collaboration and data management support for Hepatobiliary SPORE research projects, developmental research and career enhancement projects, and other cores in the SPORE.

The core also provides data management for clinical trials, monitors adverse events and prepares data summaries for manuscript preparation. The Biostatistics and Bioinformatics Core works closely with the Hepatobiliary SPORE's other cores to ensure a smooth continuum of data flow for clinical trials.

Other responsibilities of the Biostatistics and Bioinformatics Core include:

  • Providing statistical and bioinformatics collaboration for each of the SPORE projects, Developmental Research Program projects, Career Enhancement Program projects and other cores. The core provides SPORE investigators access to expertise in collaborative development of study designs and analysis plans, state-of-the-art data analysis and interpretation, data management resources, and abstract and manuscript preparation. Bioinformatics support includes sequencing alignment, variant calling, data analysis and quality assurance, pathway analysis, and access to and analysis of data in public databases.
  • Providing management and integration of existing and newly collected data through consistent and compatible data handling. Support includes database development, data forms development and processing, data collection, data archiving, quality control, and management of information related to gene mutation identification. The core is also developing a centralized database to organize processed level-3 molecular and genomic data and to connect these data with registry databases for detailed clinical records, follow-up information, and the availability of tissue and blood biospecimens.
  • Supporting the Biospecimen and Pathology Core in providing resources to the research community. This includes providing efficient and prompt access to biospecimen resources and ensuring that biospecimens and related patient information are protected and used in the highest quality research. This function is accomplished through consultation and mentoring on study design and detailed analysis during sample selection. The Biostatistics and Bioinformatics Core is also connected to the data management and centralization system of the Hepatobiliary SPORE's Biospecimen and Pathology Core to facilitate collaboration and data reuse.