Rochester, Minnesota




The primary research interests of Qian Shi, Ph.D., are in the area of the conduct and methodology of clinical trials in cancer. Dr. Shi works to develop innovative statistical study design to run more efficient clinical trials that deliver effective, novel treatments to cancer patients. Additional areas of active research include evaluation and methodology of surrogate endpoints, meta-analyses of individual patient data from a large collection of clinical trials, survival analysis, and prognostic and predictive biomarker analysis.

Focus areas

Dr. Shi is involved in multiple ongoing clinical trials of both therapeutic and surgical cancer treatment. She provides statistical design and supervises study monitoring including patient safety, data collection and statistical analyses.

Dr. Shi leads the Sargent's Hypothesis Analysis in the Research of Endpoints (SHARE) team. This independent statistics and data center team supports meta-database integration and analysis projects for the following large international collaborations:

  • Adjuvant Colon Cancer End Points (ACCENT) group
  • Analysis and Research in Cancers of the Digestive System (ARCAD) group
  • International Duration Evaluation of Adjuvant Chemotherapy (IDEA) collaboration
  • Follicular Lymphoma Analysis of Surrogate Hypothesis (FLASH) group
  • Surrogate Endpoint in Aggressive Lymphoma (SEAL) group

Significance to patient care

The research conducted by Dr. Shi contributes to an increased understanding of tumor genetics and patient factors that make disease more or less aggressive. When successful, the clinical trials that Dr. Shi participates in directly result in new treatment options for patients with cancer.

Professional highlights

  • Lead consulting statistician, Gastrointestinal Cancer Program, Mayo Clinic Cancer Center, 2016-present
  • Lead statistician, Gastrointestinal Committee, Statistics and Data Center, Alliance for Clinical Trials in Oncology, 2016-present
  • Associate Director for Statistics, Statistics and Data Center, Alliance for Clinical Trials in Oncology, 2015-present


See my publications


Primary Appointment

  1. Consultant, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research

Academic Rank

  1. Professor of Biostatistics
  2. Professor of Oncology


  1. PhD - Biostatistics Thesis title: Bayesian Methods of Evaluation and Use of Surrogate Endpoints in Single-Trial Settings. Thesis Advisors: Mary Kathryn Cowles and Kathryn Chaloner. University of Iowa
  2. MS - Biostatistics University of Iowa
  3. BS - Pharmaceutics China Pharmaceutical University

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