Publications

1. Charbonneau M, Harper K, Brochu-Gaudreau K, Perreault A, Roy LO, Lucien F, Tian S, Fortin D, Dubois CM. The development of a rapid patient-derive d xenograft model to predict chemotherapeutic drug sensitivity/resistance in malignant glial tumors. Neuro Oncol. 2023 Feb 23 [Epub ahead of print]
   View PubMed
2. Mahmoud AM, Nabavizadeh R, Rodrigues Pessoa R, Garg I, Orme J, Costello BA, Cheville J, Lucien F. Antibody-Based Therapeutics for the Treatment of Renal Cell Carcinoma: Challenges and Opportunities. Oncologist. 2023 Feb 6 Epub 2023 Feb 06
   View PubMed
3. Lucien F, Kim Y, Qian J, Orme JJ, Zhang H, Arafa A, Abraha F, Thapa I, Tryggestad EJ, Harmsen WS, Kosti J, Ali H, Lowe VJ, Johnson GB, Kwon ED, Dong H, Park SS. Tumor-Derived Extracellular Vesicles Predict Clinical Outcomes in Oligometastatic Prostate Cancer and Suppress Antitumor Immunity. Int J Radiat Oncol Biol Phys. 2022 Nov 15; 114 (4):725-737 Epub 2022 June 04
   View PubMed
4. Zhu M, Chen C, Foster NR, Hartley C, Mounajjed T, Salomao MA, Fruth BF, Beamer SE, Kim Y, Harrington SM, Pitot HC, Sanhueza CT, Feng Y, Herrmann J, McWilliams RR, Lucien F, Huang BQ, Ma WW, Bekaii-Saab TS, Dong H, Wigle D, Ahn DH, Hallemeier CL, Blackmon S, Yoon HH. Pembrolizumab in Combination with Neoadjuvant Chemoradiotherapy for Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction. Clin Cancer Res. 2022 Jul 15; 28 (14):3021-3031
   View PubMed
5. Kim Y, van der Pol E, Arafa A, Thapa I, J Britton C, Kosti J, Song S, Joshi VB, M Erickson R, Ali H, Lucien F. Calibration and standardization of extracellular vesicle measurements by flow cytometry for translational prostate cancer research. Nanoscale. 2022 Jul 14; 14 (27):9781-9795 Epub 2022 July 14
   View PubMed
6. Liu C, Zhang G, Xiang K, Kim Y, Lavoie RR, Lucien F, Wen T. Targeting the immune checkpoint B7-H3 for next-generation cancer immunotherapy. Cancer Immunol Immunother. 2022 Jul; 71 (7):1549-1567 Epub 2021 Nov 05
   View PubMed
7. Mahmoud AM, Frank I, Orme JJ, Lavoie RR, Thapa P, Costello BA, Cheville JC, Gupta S, Dong H, Lucien F. Evaluation of PD-L1 and B7-H3 expression as a predictor of response to adjuvant chemotherapy in bladder cancer. BMC Urol. 2022 Jun 24; 22 (1):90 Epub 2022 June 24
   View PubMed
8. Davidson TM, Foster N, Lucien F, Markovic S, Dong H, Winters JL, Park SS, Orme JJ. Rescuing Cancer Immunity by Plasma Exchange in Metastatic Melanoma (ReCIPE-M1): protocol for a single-institution, open-label safety trial of plasma exchange to clear sPD-L1 for immunotherapy. BMJ Open. 2022 May 12; 12 (5):e050112
   View PubMed
9. Northrop-Albrecht EJ, Taylor WR, Huang BQ, Kisiel JB, Lucien F. Assessment of extracellular vesicle isolation methods from human stool supernatant. J Extracell Vesicles. 2022 Apr; 11(4):e12208.
   View PubMed
10. Wen T, Barham W, Li Y, Zhang H, Gicobi JK, Hirdler JB, Liu X, Ham H, Peterson Martinez KE, Lucien F, Lavoie RR, Li H, Correia C, Monie DD, An Z, Harrington SM, Wu X, Guo R, Dronca RS, Mansfield AS, Yan Y, Markovic SN, Park SS, Sun J, Qin H, Liu MC, Vasmatzis G, Billadeau DD, Dong H. NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy. Cancer Immunol Res. 2022 Feb; 10 (2):162-181 Epub 2021 Dec 15
    View PubMed
11. Lucien F, Benarroch EE, Mullan A, Ali F, Boeve BF, Mielke MM, Petersen RC, Kim Y, Stang C, Camerucci E, Ross OA, Wszolek ZK, Knopman D, Bower J, Singer W, Savica R. Poly (ADP-Ribose) and a-synuclein extracellular vesicles in patients with Parkinson disease: A possible biomarker of disease severity. PLoS One. 2022; 17(4):e0264446. Epub 2022 Apr 08.
    View PubMed
12. Power EA, Fernandez-Torres J, Zhang L, Yaun R, Lucien F, Daniels DJ. Chorioallantoic membrane (CAM) assay to study treatment effects in diffuse intrinsic pontine glioma. PLoS One. 2022; 17 (2):e0263822 Epub 2022 Feb 14
    View PubMed
13. Zhang H, Orme JJ, Abraha F, Stish BJ, Lowe VJ, Lucien F, Tryggestad EJ, Bold MS, Pagliaro LC, Choo CR, Brinkmann DH, Iott MJ, Davis BJ, Quevedo JF, Harmsen WS, Costello BA, Johnson GB, Nathan MA, Olivier KR, Pisansky TM, Kwon ED, Dong H, Park SS. Phase II Evaluation of Stereotactic Ablative Radiotherapy (SABR) and Immunity in (11)C-Choline-PET/CT-Identified Oligometastatic Castration-Resistant Prostate Cancer. Clin Cancer Res. 2021 Dec 1; 27 (23):6376-6383 Epub 2021 Sept 30
    View PubMed
14. Lavoie RR, Gargollo PC, Ahmed ME, Kim Y, Baer E, Phelps DA, Charlesworth CM, Madden BJ, Wang L, Houghton PJ, Cheville J, Dong H, Granberg CF, Lucien F. Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion. Cancers (Basel). 2021 Sep 9; 13 (18) Epub 2021 Sept 09
    View PubMed
15. Bansal A, Pandey MK, Barham W, Liu X, Harrington SM, Lucien F, Dong H, Park SS, DeGrado TR. Non-invasive immunoPET imaging of PD-L1 using anti-PD-L1-B11 in breast cancer and melanoma tumor model. Nucl Med Biol. 2021 Sep-Oct; 100-101:4-11. Epub 2021 May 29.
    View PubMed
16. Vanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS. A size-exclusion-based approach for purifying extracellular vesicles from human plasma. Cell Rep Methods. 2021 Jul 26; 1 (3)
    View PubMed
17. Cox MJ, Lucien F, Sakemura R, Boysen JC, Kim Y, Horvei P, Manriquez Roman C, Hansen MJ, Tapper EE, Siegler EL, Forsman C, Crotts SB, Schick KJ, Hefazi M, Ruff MW, Can I, Adada M, Bezerra E, Kankeu Fonkoua LA, Nevala WK, Braggio E, Ding W, Parikh SA, Kay NE, Kenderian SS. Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia. Mol Ther. 2021 Apr 07; 29(4):1529-1540. Epub 2021 Jan 01.
    View PubMed
18. Lok UW, Trzasko JD, Huang C, Tang S, Gong P, Kim Y, Lucien F, Lowerison MR, Song P, Chen S. Improved Ultrasound Microvessel Imaging Using Deconvolution with Total Variation Regularization. Ultrasound Med Biol. 2021 Apr; 47(4):1089-1098. Epub 2021 Jan 16.
    View PubMed
19. Lok UW, Huang C, Gong P, Tang S, Yang L, Zhang W, Kim Y, Korfiatis P, Blezek DJ, Lucien F, Zheng R, Trzasko JD, Chen S. Fast super-resolution ultrasound microvessel imaging using spatiotemporal data with deep fully convolutional neural network. Phys Med Biol. 2021 Mar 23; 66(7).
    View PubMed
20. Minkler S, Lucien F, Kimber MJ, Sahoo DK, Bourgois-Mochel A, Musser M, Johannes C, Frank I, Cheville J, Allenspach K, Mochel JP. Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man's Trash Is Another Man's Treasure. Cancers (Basel). 2021 Jan 23; 13(3).
    View PubMed
21. Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H. IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology. 2020 Oct; 159(4):1487-1503.e17. Epub 2020 Jun 20.
    View PubMed
22. Lowerison MR, Huang C, Kim Y, Lucien F, Chen S, Song P. In Vivo Confocal Imaging of Fluorescently Labeled Microbubbles: Implications for Ultrasound Localization Microscopy. IEEE Trans Ultrason Ferroelectr Freq Control. 2020 Sep; 67(9):1811-1819. Epub 2020 Apr 15.
    View PubMed
23. Kim T, Kim Y, Lucien F, Zhao Y, Enninga EAL. Decreased gremlin 1 expression in women with BMI =35 kg/m2 is mediated by interleukin 10 and interleukin 1ß in the follicular fluid. F S Sci. 2020 Aug; 1(1):16-26. Epub 2020 Jun 29.
    View PubMed
24. Orme JJ, Enninga EAL, Lucien-Matteoni F, Dale H, Burgstaler E, Harrington SM, Ball MK, Mansfield AS, Park SS, Block MS, Markovic SN, Yan Y, Dong H, Dronca RS, Winters JL. Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles. J Immunother Cancer. 2020 Aug; 8 (2)
    View PubMed
25. Himes BT, Peterson TE, de Mooij T, Garcia LMC, Jung MY, Uhm S, Yan D, Tyson J, Jin-Lee HJ, Parney D, Abukhadra Y, Gustafson MP, Dietz AB, Johnson AJ, Dong H, Maus RL, Markovic S, Lucien F, Parney IF. The role of extracellular vesicles and PD-L1 in glioblastoma-mediated immunosuppressive monocyte induction. Neuro Oncol. 2020 Jul 7; 22 (7):967-978
    View PubMed
26. Lowerison MR, Huang C, Lucien F, Chen S, Song P. Ultrasound localization microscopy of renal tumor xenografts in chicken embryo is correlated to hypoxia. Sci Rep. 2020 Feb 12; 10 (1):2478
    View PubMed
27. Orme JJ, Jazieh KA, Xie T, Harrington S, Liu X, Ball M, Madden B, Charlesworth MC, Azam TU, Lucien F, Wootla B, Li Y, Villasboas JC, Mansfield AS, Dronca RS, Dong H. ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance. Oncoimmunology. 2020; 9(1):1744980. Epub 2020 Apr 14.
    View PubMed
28. Guo Q, Furuta K, Lucien F, Gutierrez Sanchez LH, Hirsova P, Krishnan A, Kabashima A, Pavelko KD, Madden B, Alhuwaish H, Gao Y, Revzin A, Ibrahim SH. Integrin ß1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH. J Hepatol. 2019 Dec; 71(6):1193-1205. Epub 2019 Aug 06.
    View PubMed
29. Joncas FH, Lucien F, Rouleau M, Morin F, Leong HS, Pouliot F, Fradet Y, Gilbert C, Toren P. Plasma extracellular vesicles as phenotypic biomarkers in prostate cancer patients. Prostate. 2019 Nov; 79 (15):1767-1776 Epub 2019 Sept 02
    View PubMed
30. Li J, Liu H, Mauer AS, Lucien F, Raiter A, Bandla H, Mounajjed T, Yin Z, Glaser KJ, Yin M, Malhi H. Characterization of Cellular Sources and Circulating Levels of Extracellular Vesicles in a Dietary Murine Model of Nonalcoholic Steatohepatitis. Hepatol Commun. 2019 Sep; 3(9):1235-1249. Epub 2019 Jul 10.
    View PubMed
31. Mesci A, Lucien F, Huang X, Wang EH, Shin D, Meringer M, Hoey C, Ray J, Boutros PC, Leong HS, Liu SK. RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer. Journal of Translational Medicine. 2019.
    View PubMed
32. Huang C, Lowerison MR, Lucien F, Gong P, Wang D, Song P, Chen S. Noninvasive Contrast-Free 3D Evaluation of Tumor Angiogenesis with Ultrasensitive Ultrasound Microvessel Imaging. Scientific Reports. 2019.
    View PubMed
33. Lucien F, Leong HS. The role of extracellular vesicles in cancer microenvironment and metastasis: myths and challenges. Biochemical Society Transactions. 2019.
    View PubMed
34. Lucien F, Lac V, Billadeau DD, Borgida A, Gallinger S, Leong HS. Glypican-1 and glycoprotein 2 bearing extracellular vesicles do not discern pancreatic cancer from benign pancreatic diseases. Oncotarget. 2019.
    View PubMed
35. Gomes J, Lucien F, Cooper TT, Kim Y, Williams KC, Liao X, Kaufman L, Lagugné-Labarthet F, Kenyon O, Boysen J, Kay NE, McIntyre CW, Leong HS. Analytical Considerations in Nanoscale Flow Cytometry of Extracellular Vesicles to Achieve Data Linearity. Thrombosis & Haemostasis. 2018.
    View PubMed
36. Massonneau J, Ouellet C, Lucien F, Dubois CM, Tyler J, Boissonneault G. Suboptimal extracellular pH values alter DNA damage response to induced double-strand breaks. FEBS Open Bio. 2018 Mar; 8 (3):416-425 Epub 2018 Feb 16
    View PubMed
37. Tornin J, Hermida-Prado F, Padda RS, Gonzalez MV, Alvarez-Fernandez C, Rey V, Martinez-Cruzado L, Estupiñan O, Menendez ST, Fernandez-Nevado L, Astudillo A, Rodrigo JP, Lucien F, Kim Y, Leong HS, Garcia-Pedrero JM, Rodriguez R. FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway. Neoplasia. 2018.
    View PubMed
38. Lucien F, Lavoie RR, Dubois CM. Targeting endosomal pH for cancer chemotherapy. Mol Cell Oncol. 2018; 5 (3):e1435184 Epub 2018 Mar 13
    View PubMed
39. Lucien F, Pelletier PP, Lavoie RR, Lacroix JM, Roy S, Parent JL, Arsenault D, Harper K, Dubois CM. Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance. Nat Commun. 2017 Jun 21; 8:15884 Epub 2017 June 21
    View PubMed
40. Brett SI, Lucien F, Guo C, Williams KC, Kim Y, Durfee PN, Brinker CJ, Chin JI, Yang J, Leong HS. Immunoaffinity based methods are superior to kits for purification of prostate derived extracellular vesicles from plasma samples. Prostate. 2017.
    View PubMed
41. Trensz F, Lucien F, Couture V, Sollrald T, Drouin G, Rouleau AJ, Grandbois M, Lacraz G, Grenier G. Increased microenvironment stiffness in damaged myofibers promotes myogenic progenitor cell proliferation. Skelet Muscle. 2015; 5:5 Epub 2015 Feb 17
    View PubMed
42. Lucien F, Harper K, Pelletier PP, Volkov L, Dubois CM. Simultaneous pH measurement in endocytic and cytosolic compartments in living cells using confocal microscopy. J Vis Exp. 2014 Apr 28; (86)
    View PubMed
43. Arsenault D, Lucien F, Dubois CM. Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface. J Cell Physiol. 2012 Feb; 227 (2):789-800
    View PubMed
44. Lucien F, Brochu-Gaudreau K, Arsenault D, Harper K, Dubois CM. Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK). PLoS One. 2011; 6 (12):e28851 Epub 2011 Dec 27
    View PubMed
45. Harper K, Arsenault D, Boulay-Jean S, Lauzier A, Lucien F, Dubois CM. Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation. Cancer Res. 2010 Jun 1; 70 (11):4634-43 Epub 2010 May 18
    View PubMed