SUMMARY
Fabrice Lucien-Matteoni, PhD., is a cancer cell biologist who investigates the functional roles of cell-surface proteins and extracellular vesicles in genitourinary cancers (prostate, kidney, bladder). The primary goal of Dr. Lucien-Matteoni's Surfaceome and Extracellular Vesicles Laboratory is to understand the functional roles of tumor-derived extracellular vesicles in tumor progression and translate discoveries into effective cancer therapies. Dr. Lucien-Matteoni's lab uses advanced technologies such as cell-surface proteomics, nanoscale flow cytometry and in vivo models.
Dr. Lucien-Matteoni is also committed to identifying novel plasma and urinary extracellular vesicle-based biomarkers for use in the diagnosis and prognosis of genitourinary cancers. By using nanoscale flow cytometry and immunocapture strategies, he is investigating the molecular composition of tumor-derived extracellular vesicles in hundreds of blood and urine samples collected from patients with cancer.
Focus areas
- Defining the roles of tumor-derived extracellular vesicles in response to therapy
- Developing extracellular vesicle-based liquid biopsies for the management of genitourinary cancers
- Dissecting molecular and cellular mechanisms of cancer-associated cell-surface proteins
Significance to patient care
Efforts by Dr. Lucien-Matteoni and his team are directed toward developing minimally invasive strategies for improving detection and monitoring treatment response in genitourinary cancers. In addition, a better understanding of the role of tumor-derived extracellular vesicles paves the way for developing new therapeutic strategies and overcoming tumor resistance to conventional therapies.