Rochester, Minnesota




Fabrice Lucien-Matteoni, PhD., is a cancer cell biologist who investigates the functional roles of cell-surface proteins and extracellular vesicles in genitourinary cancers (prostate, kidney, bladder). The primary goal of Dr. Lucien-Matteoni's Surfaceome and Extracellular Vesicles Laboratory is to understand the functional roles of tumor-derived extracellular vesicles in tumor progression and translate discoveries into effective cancer therapies. Dr. Lucien-Matteoni's lab uses advanced technologies such as cell-surface proteomics, nanoscale flow cytometry and in vivo models.

Dr. Lucien-Matteoni is also committed to identifying novel plasma and urinary extracellular vesicle-based biomarkers for use in the diagnosis and prognosis of genitourinary cancers. By using nanoscale flow cytometry and immunocapture strategies, he is investigating the molecular composition of tumor-derived extracellular vesicles in hundreds of blood and urine samples collected from patients with cancer.

Focus areas

  • Defining the roles of tumor-derived extracellular vesicles in response to therapy
  • Developing extracellular vesicle-based liquid biopsies for the management of genitourinary cancers
  • Dissecting molecular and cellular mechanisms of cancer-associated cell-surface proteins

Significance to patient care

Efforts by Dr. Lucien-Matteoni and his team are directed toward developing minimally invasive strategies for improving detection and monitoring treatment response in genitourinary cancers. In addition, a better understanding of the role of tumor-derived extracellular vesicles paves the way for developing new therapeutic strategies and overcoming tumor resistance to conventional therapies.


Primary Appointment

  1. Associate Consultant I, Department of Immunology

Administrative Appointment

  1. Associate Consultant I-Research, Department of Urology

Academic Rank

  1. Assistant Professor of Urology


  1. Ph.D. - Immunology University of Sherbrooke
  2. MSc - Immunology University of Sherbrooke
  3. BSc - Biological Sciences University of Sherbrooke
  4. BSc - Biology University of Toulon

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