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Laboratories

Vector and Vaccine Engineering: Michael A. Barry

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    • Projects
    • Gene therapy for muscular dystrophy
    • Gene therapy for propionic acidemia
    • Metabolic biotinylation
    • Vector targeting and purification
    • Biotinylated vectors as ligand screening platforms
    • Biotin tags as cryo-EM tags
    • Models for cell targeting
    • Mucosal vaccines
    • Oncolytic adenovirus for cancer therapy
    • Polymer shielding of vectors and vaccines
    • Optical imaging to track ligands
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Gene Therapy for Muscular Dystrophy

Researchers are studying vector targeting and vector detargeting to improve the pharmacology of both adenovirus and adeno-associated virus vectors for muscle gene therapy. The team is currently focused on expressing dysferlin for dysferlinopathies.

Learn about gene therapy research approaches for muscular dystrophy.

Gene Therapy for Propionic Acidemia

The team is testing gene therapy using adenoviral and adeno-associated virus vectors.
Take a closer look at propionic acidemia research.

Metabolic Biotinylation

Dr. Barry and his team are developing metabolic biotinylation technologies that target any cell type using one or more vector platforms.

Find out more about metabolic biotinylation in the lab.

Vector Targeting and Purification

Researchers in the lab are studying how modified vectors fail, how the affinity of the ligands affects this process and how one might use or avoid this biology to maximize vector specificity.

Learn more about vector targeting and purification through screening viral capsomeres as scaffolds.

Biotinylated Vectors as Ligand Screening Platforms

Dr. Barry and the team are using metabolic biotinylated vector technology to prescreen ligands on various targeting models.

Learn about biotinylated vectors as ligand screening platforms in the lab.

Biotin Tags as Cryo-EM Tags

The team is studying capsomers and applying cryo-electron microscopy (cryo-EM) tags to better understand the biology of native and engineered cell-targeting viruses.

Read about biotin tags as cryo-EM tags in the lab.

Models for Cell Targeting

The team is directing ligand and vector targeting efforts against several cell targets, selected for distinct biological and pharmacological issues.

See a chart with models for cell targeting and learn more about this research.

Mucosal Vaccines

The lab is testing approaches to maximize antigen delivery to mucosal surfaces and developing mucosal vaccines against HIV-1, influenza and bioweapons.

Read more about mucosal vaccines against HIV-1, influenza and bioweapons.

Oncolytic Adenovirus for Cancer Therapy

The team is studying specific oncolytic adenoviruses targeting breast cancer, chronic lymphocytic leukemia, myeloma and cancer stem cells.

Learn about oncolytic adenovirus for cancer therapy.

Polymer Shielding of Vectors and Vaccines

The team is testing polyethylene glycol and other polymers for their shielding and protective functions for liver gene therapy, for cancer therapy and during vaccination.

Learn about research in polymer shielding of vectors and vaccines.

Optical Imaging to Track Ligands

Researchers in the lab are applying optical imaging approaches that can be utilized for gene therapy, vaccine and cancer projects.

Read more about optical imaging in the lab.
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