Dr. Mukhopadhyay's lab uses wild-type and knockout murine models and zebrafish models to study how proteins affect vascular permeability, angiogenesis and heart morphology. The models allow our research team to gain a better understanding of vascular permeability by monitoring it in real time. Here, explore related research images.
This image shows the effect of dopamine on vascular permeability as induced by bradykinin (BK), platelet-activating factor (PAF) and vascular permeability factor/vascular endothelial growth factor (VPF/VEGF).
This image shows the heart morphology of wild-type mice (left) and smooth muscle protein 22-NRP1 knockout mice (right). The knockout mice are deficient in NRP1 in cardiomyoctyes and smooth muscle cells and show enlarged right ventricles.
This image shows echocardiography of wild-type mice (left) and smooth muscle protein 22α-NRP1 knockout mice (right).
This is a confocal image of the head vessels of a 3-day-old Fli:GFP zebrafish embryo, showing a lateral view, anterior to posterior.
This is a confocal image of intersegmental vessels of a 3-day-old zebrafish embryo.
This image, taken with Zeiss axio observer Z1, shows a microangiogram of a 3-day-old zebrafish embryo.
This is a representative image of a 4-day-old zebrafish embryo expressing cas9 in its heart.