PDX Phenotypes

To help researchers plan for experiments and studies, the PDX National Resource offers information about growth characteristics, invasiveness and subtypes for patient-derived xenografts, along with tissue microarray data and de-identified clinical data from patient electronic records.

  • Growth characteristics. The growth rates of glioblastoma patient-derived xenografts vary widely. To help facilitate planning for experiments, the PDX National Resource has tabulated the approximate growth rates of each PDX line. Read more about growth characteristics.
  • Invasiveness. Glioblastoma is highly invasive. The PDX National Resource has characterized the invasiveness of many of the patient-derived xenograft models when they're grown as intracranial tumors. Read more about invasiveness.
  • Molecular subtype. DNA from tumors were analyzed and methylomic data were analyzed to assign a TCGA subtype, providing molecular groupings for PDX lines in the PDX National Resource. Read more about molecular subtypes.
  • Tissue microarray data. To facilitate assessment of molecular features across multiple patient-derived xenograft models by immunohistochemistry, orthotopic tumors were selected based on review of the hematoxylin and eosin slides for inclusion in a tissue microarray. Read more about tissue microarray data.
  • Clinical information. Limited, de-identified clinical information has been abstracted retrospectively from the electronic medical record for each patient from whom a viable patient-derived xenograft model was developed. Read more about clinical information.