Molecular Subtype

The Cancer Genome Atlas (TCGA) has defined three glioblastoma molecular subtypes based on an analysis of gene expression data. Using RNAseq obtained from orthotopic tumors, these tumors were classified as proneural, classical or mesenchymal.

Similarly, DNA from flank tumors was analyzed using the Illumina MethylationEPIC BeadChip array. The methylomic data were analyzed to assign a TCGA subtype in the Mayo Clinic Brain Tumor Patient-Derived Xenograft National Resource.

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