Whole-ExomeSeq Method

Whole-exome sequencing (WES) was performed on flank tumor tissue from a single biological sample for each patient-derived xenograft model in the Mayo Clinic Brain Tumor Patient-Derived Xenograft National Resource.

When available, germline DNA from the corresponding patient was also run. WES was performed at two different institutions — Translational Genomics Research Institute (TGen) and the Medical Genome Facility at Mayo Clinic — with different platforms.

WES from both Mayo Clinic and TGen was run through a common bioinformatics pipeline.

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