About Dr. Kenderian

Saad J. Kenderian, M.B., Ch.B., is an assistant professor of medicine, immunology and oncology at Mayo Clinic College of Medicine and Science. His principal research interests are developing and optimizing novel-engineered cell therapy approaches for the treatment of diseases.

Research in the T Cell Engineering Lab is focused on cellular engineering and gene and viral therapy, specifically on the development and optimization of engineered cell therapies for the treatment of diseases. His clinical expertise is in the management of patients with chronic lymphocytic leukemia, patients treated with CAR-T cell therapy and bone marrow transplantation.

He completed a fellowship in hematology and medical oncology at Mayo School of Graduate Medical Education (now Mayo Clinic School of Graduate Medical Education) and received a Mayo Clinic scholar award in 2013. Dr. Kenderian joined the translational research program in the laboratory of Carl H. June, M.D., of the University of Pennsylvania in Philadelphia, where he worked under the direction of Dr. June and Saar Gill, M.D., Ph.D. His work involved the development of novel chimeric antigen receptor (CAR)-T cell therapy for acute myeloid leukemia as well as different strategies to improve CAR-T cell therapy for lymphoid malignancies.

Dr. Kenderian's laboratory employs multiple tools for cellular engineering and development of gene and cell therapies, including standard cloning techniques, lentiviral transduction, retrovirus constructs, oncolytic viruses, mesenchymal stromal cells, T cell functional assays, patient-derived xenograft immunodeficient mouse models, humanized mouse models, syngeneic models, multiparameter flow cytometry, bioluminescent imaging, multiplex cytokine analysis and genome engineering tools.