In the Structural Biology Facility, users — from beginners to experts — are provided the necessary training, advice and resources to carry out their own experiments. This includes assistance with supplies and instruments, protein expression, purification, crystallization, structure determination, model building and refinement, drug discovery, and paper and grant writing.

The facility's focus is on helping investigators to do hands-on X-ray crystallography work themselves, as well as on developing long-term relationships. It is common for projects to run for one to four years.

Research collaborations also include access to automation, instrumentation and effort in the University of Minnesota's Nanoliter Crystallization Facility, as well as occasional use of the university's Kahlert Structural Biology Laboratory, which was funded in part through the Minnesota Partnership for Biotechnology and Medical Genomics.