Molecular Phenotyping of Musculoskeletal Tissues and Diseases
Intracellular collagen proteins (in green) before they are secreted and deposited by human mesenchymal stem cells derived from adipose tissue. The cell nuclei are shown in blue.
The actin filament organization (red) is coupled with human mesenchymal stem cells (blue).
Using next-generation RNA-sequencing technology, Dr. van Wijnen has assembled a database containing the transcriptomic profiles of more than 1,000 human cell types and tissues. This database, called a musculoskeletal tissue atlas, provides a powerful tool for analyzing different tissue types and disease states relating to the musculoskeletal system.
Using the musculoskeletal tissue atlas, Dr. van Wijnen's team of investigators in the Stem Cell Therapy and Skeletal Regeneration Laboratory can gain a better understanding of the molecular mechanisms underlying musculoskeletal diseases and identify potential pharmacological targets for novel therapeutic strategies.