Research efforts in Dr. Doles' lab are focused on examining metabolic control of muscle stem cells, disease- and age-associated muscle wasting, and muscular dystrophy. The team works to understand how muscle stem cells (satellite cells) drive the regeneration process and how their dysfunction contributes to impaired tissue homeostasis in disease states. The lab uses a variety of tools to address these issues, including mouse models, in vitro and in vivo stem cell assays, functional genomics, single-cell genomics and metabolomics.
- Metabolic control of muscle stem cell fate
- Skeletal muscle wasting (cachexia)
- Age-associated muscle wasting (sarcopenia)
- Muscular dystrophy
Dr. Doles' Skeletal Muscle Wasting and Progenitor Cell Biology Lab is affiliated with several Mayo Clinic research and training areas:
About Dr. Doles
Jason D. Doles, Ph.D., is an assistant professor of biochemistry and molecular biology at Mayo Clinic College of Medicine and Science in Rochester, Minnesota. Dr. Doles joined Mayo Clinic in 2016 following graduate training at Massachusetts Institute of Technology (MIT) with Michael T. Hemann, Ph.D., and postdoctoral training with William (Bill) M. Keyes, Ph.D., at the Centre for Genomic Regulation (CRG) in Barcelona, Spain, as well as the University of Colorado Boulder with Bradley B. Olwin, Ph.D.
Dr. Doles has been the recipient of several major research awards.