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Microcomputed tomography reconstructions of cortical bone (left), cancellous bone (middle) and bone marrow fat (yellow, right) in Hdac3-depleted mice. Credit: Meghan McGee-Lawrence, Ph.D., Dana L. Begun, Ph.D.
Dr. Westendorf's Skeletal Development and Regeneration Research Laboratory is studying histone deacetylases in bone development and bone diseases.
This project in Dr. Westendorf's lab is designed to determine how Hdacs and associated epigenetic factors control bone development and disease. This work is clinically significant because Hdac inhibitors and other epigenetic drugs are entering the clinic at rapid rates for the treatment of cancer and many other conditions.
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