Multi-Parametric Magnetic Resonance Imaging (MRI) in Kidney and Cardiovascular Disease
Magnetic resonance imaging (MRI) is a powerful modality. Functional MRI encompasses a large variety of techniques measuring diverse physiological markers in many organs.
MRI uniquely acquires detailed information without imposing ionizing radiation, and many applications don't require contrast agents. Although renal functional MRI tools are still largely experimental, understanding their inherent power may facilitate adaptation for clinical practice.
Dr. Lerman's Renovascular Disease Lab has several ongoing projects that aim to assess renal and cardiac hemodynamics and function in small animal models using high-field MRI, as well as in large animal models and human research participants using clinical 3T MRI.
MRI methods used in Dr. Lerman's Multi-Parametric Magnetic Resonance Imaging (MRI) in Kidney and Cardiovascular Disease research project include:
- Dynamic contrast-enhanced imaging
- Arterial spin labeling
- Diffusion-weighted imaging
- Blood oxygen level-dependent imaging (BOLD-MRI)
- Manganese-enhanced MRI
- Myocardial tagging
In addition, a major focus of the Renovascular Disease Lab is on the assessment of renal fibrosis.
MR elastography has been applied in swine with renal artery stenosis to assess renal cortical and medullary elasticity. Dr. Lerman's lab has been characterizing magnetization transfer imaging in mice and pigs for assessment of renal macromolecules, such as collagen, as an index of fibrosis.
For more information about the Renovascular Disease Lab's research project on MRI in kidney and cardiovascular disease, email Kai Jiang, Ph.D.