High-Resolution Computerized Tomography (CT) and Cardiovascular Disease

For years, cardiovascular disease has been the No. 1 cause of death in the United States. For this reason, research to develop and assess new diagnostic techniques and therapies for fighting cardiovascular disease is a top health care priority.

This research project in Dr. Lerman's Renovascular Disease Lab aims to develop and apply high-resolution computerized tomography (CT) methods to detect and explore the effects of risk factors for cardiovascular disease, such as hypertension and hypercholesterolemia, on the myocardial and renal microvessels.

Using advanced medical imaging techniques, researchers in Dr. Lerman's lab are able to identify the structural and functional changes of microcirculation in the heart and kidneys in order to develop and evaluate new approaches to these pathogenic conditions.

These studies are likely to shed important light on the mechanisms of atherosclerotic heart and kidney disease, and suggest new preventive and interventional measures.

The Renovascular Disease Lab also has adopted and developed new applications for a novel imaging technique with high-resolution micro-CT, which can identify early changes in the cardiac and renal vascular structure.

Dr. Lerman's lab also is investigating transplantation of endothelial progenitor cells or mesenchymal stem cells in atherosclerotic renal artery disease.

The future direction of this research is seeking better candidates for the cell therapy of cardiovascular diseases. Dr. Lerman's team is studying the ability of endogenous renal resident progenitor and stem cells to repair neighboring tubular cells.

Project contact

For more information about the Renovascular Disease Lab's research project on high-resolution computerized tomography and cardiovascular disease, email Xiang Y. Zhu, M.D., Ph.D.