Peripheral Nerve Repair and Regeneration (PNR)

Peripheral nerve repair and regeneration research focuses on developing synthetic nerve conduits as an alternative to autologous nerve graft to repair segmental nerve defects.

A first-generation polycaprolactone fumarate (PCLF) nerve conduit is currently undergoing GMP upscaling and FDA clearance to move toward clinical trial. Co-polymerizing PCLF with polypyrrole renders PCLF-Ppy conduits conductive.

Second-generation conduits are currently under development. The new generation conduits can deliver an electric current across the repair site, which can potentially benefit nerve regeneration.

Various electrical stimulation paradigms are being tested using both in vitro and in vivo experimental systems. Other aspects of the research efforts include examining the roles of growth factors, stem cells and conditions such as ischemia, fibrosis and delayed repair on nerve regeneration and functional recovery.

Project Personnel

  • Jarred J. Nesbitt
  • Robert J. Spinner, M.D.
  • Huan Wang, M.D., Ph.D.
  • Shuya Zhang