Role of RORbeta With Mediating Bone Loss With Aging
Dr. Khosla's Osteoporosis and Bone Biology Laboratory recently identified a novel transcription factor, called RORbeta, that regulates bone formation.
RORbeta markedly inhibits bone formation. The level of RORbeta increases with aging in mice and humans.
In this research project, Dr. Khosla's lab is testing the possibility that eliminating RORbeta, using either global or cell-specific knockout mice, will attenuate or prevent bone loss with aging.
Dr. Khosla and his research team are engaged in a number of mechanistic studies related to defining how RORbeta regulates bone formation.