About the Lab

The goal of the Osteoporosis and Bone Biology Laboratory at Mayo Clinic is to develop new diagnostic and therapeutic approaches for osteoporosis, a growing public health problem around the world.

The Osteoporosis and Bone Biology Lab uses cell and mouse models, intensive mechanistic human studies in the Clinical Research and Trials Unit (CRTU) at Mayo Clinic, and population studies to address this goal and better understand the pathophysiology of age-related bone loss and fractures.

The lab's research projects focus on bone loss related to aging, estrogen, RORbeta and type 2 diabetes.

The Osteoporosis and Bone Biology Laboratory is located within the Robert and Arlene Kogod Center on Aging, with access to both extensive research collaborations and equipment.

The lab is led by Sundeep Khosla, M.D., a clinical investigator and translational scientist at Mayo Clinic in Rochester, Minnesota, along with David G. Monroe, Ph.D., a basic cell and molecular biologist at Mayo Clinic in Rochester. The complementary expertise of Drs. Khosla and Monroe allows the lab to examine scientific problems at physiological and cellular levels using human and mouse models.