About Student Research

David Tse (2017–present)

DNA looping when proteins are involved

David H. Tse grew up in Malaysia, receiving his undergraduate degree from Houghton College in New York state in 2016. He was a summer undergraduate research fellow in Dr. Maher's lab at Mayo Clinic in 2015.

Though threadlike when viewed from a distance, DNA is more like a rod when considered over lengths of dozens of base pairs where proteins recognize specific sequences and bind selectively. DNA resists bending, twisting and looping over these distances. Experimental tools have not yet allowed this inflexibility to be measured for the kinds of looped DNA structures that form when proteins bound to distant DNA sites interact with one another. Tse's project involves developing new massively parallel approaches that use chemical cross-linking and deep sequencing to measure the probabilities of different kinds of DNA loops that are relevant in gene control within cells.