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Laboratories

Neuroregeneration and Neurorehabilitation: Isobel A. Scarisbrick

  • About
    • About
    • About the Lab
    • Research Focus
    • Faculty and Staff
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    • Patents
  • Projects
    • Projects
    • The Role of Protease-Activated Receptors (PARs) in Spinal Cord Injury and Repair
    • Targeting Protease-Activated Receptors (PARs) to Promote Myelin Regeneration and Stem Cell Differentiation Across the Life Span
    • Targeting Myelin Metabolism to Enhance Recovery of Function After Spinal Cord Injury
    • Targeting Protease-Activated Receptors (PARs) to Overcome CNS Inflammation
    • Targeting Protease-Activated Receptors (PARs) to Treat Glioblastoma
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Myelinated axons have enhanced conduction velocity

Electron photomicrograph shows electron-dense myelin wrapping to insulate axons in the adult spinal cord, thereby facilitating nerve impulse conduction. Oligodendrocytes also support axons metabolically by providing an energy source. It is therefore essential to identify strategies to protect and regenerate oligodendrocytes, as they are vital to brain and spinal cord function.

The Role of Protease-Activated Receptors (PARs) in Spinal Cord Injury and Repair

Dr. Scarisbrick's lab is identifying the role of protease-activated receptors in mediating CNS injury and repair responses.

Learn about the project

Targeting Protease-Activated Receptors to Promote Myelin Regeneration and Stem Cell Differentiation Across the Life Span

This research project aims to identify protease-activated receptors as new targets for pharmacotherapy to promote myelin repair in the injured brain and spinal cord.

Learn about the project

Targeting Myelin Metabolism to Enhance Recovery of Function After Spinal Cord Injury

Dr. Scarisbrick's lab is testing the hypothesis that diet and exercise-induced changes in critical regulators of metabolism control the capacity of the nervous system to generate and repair myelin.

Learn about the project

Targeting Protease-Activated Receptors (PARs) to Overcome CNS Inflammation

Dr. Scarisbrick's lab studies the therapeutic utility of neuroinflammatory and neurodegenerative protease-activated receptors and their mechanism of action.

Learn about the project

Targeting Protease-Activated Receptors (PARs) to Treat Glioblastoma

This project has significant potential to improve survival in glioblastoma patients in addition to likely therapeutic utility across a range of cancers.

Learn about the project
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