About the Lab

The Neurogenesis and Brain Repair Laboratory of Mi Hyeon Jang, Ph.D., at Mayo Clinic develops novel therapeutic strategies for treating neurological diseases associated with cognitive function.

Recent advances in neuroscience have given researchers unprecedented insight into normal brain function and the pathology of neurological diseases. However, such knowledge has yet to be brought into clinical application due to an inadequate understanding of how such pathologies may be targeted for actual patient outcomes.

Aided by multiple approaches — including mouse genetics, shRNA-mediated genetic manipulations, imaging and animal behaviors — research in Dr. Jang's Neurogenesis and Brain Repair Laboratory is focused on the following research areas:

  • Adult neurogenesis. The process of generating new neurons from neural stem cells is called neurogenesis. In the mammalian brain, neurogenesis continues to occur well into adulthood in discrete regions — namely the hippocampus and olfactory bulb. Dr. Jang's lab focuses on the cellular and molecular mechanisms regulating adult hippocampal neurogenesis that play significant roles in regeneration, memory and mood regulation.
  • Remyelination. New axonal myelin sheaths are generated in the central nervous system by the process of remyelination. Although remyelination has been posited as a promising therapeutic target for myelin-related disorders such as multiple sclerosis, no effective therapies exist for myelination-related disorders due to the limited understanding of the causative pathology mediating myelination. Dr. Jang's laboratory aims to identify the molecular targets that mediate remyelination so that effective therapeutic strategies capable of promoting myelin regeneration can be realized.