Neurodegenerative Diseases: Leonard Petrucelli

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency

Neuropathological examination of sense and antisense RNA foci and c9RAN protein pathology in c9FTD/ALS

Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, motor deficits, early mortality and mitochondrial aggregation in transgenic mice

Structure/function analysis of TDP-43 neurotoxicity in Caenorhabditis elegans

CHIP facilitates the degradation of aberrant PHF-tau species by regulating the Hsp90/chaperone complex

CHIP failitates the aggregation of toxic phophorylated tau species